N‐Heterocyclic Carbene Acyl Anion Organocatalysis by Ball‐Milling
نویسندگان
چکیده
منابع مشابه
Nucleophilic β-Carbon Activation of Propionic Acid as a 3-Carbon Synthon by Carbene Organocatalysis.
Direct β-carbon activation of propionic acid (C2H5CO2H) by carbene organocatalysis has been developed. This activation affords the smallest azolium homoenolate intermediate (without any substituent) as a 3-carbon nucleophile for enantioselective reactions. Propionic acid is an excellent raw material because it is cheap, stable, and safe. This approach provides a much better solution to azolium ...
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The activation of the a-carbons of carboxylic esters and related carbonyl compounds to generate enolate equivalents as nucleophiles is one of the most powerful strategies in organic synthesis. We reasoned that the horizons of chemical synthesis could be greatly expanded if the typically inert b-carbons of saturated esters could be used as nucleophiles. However, despite the rather significant fu...
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Spiroheterocycles are regarded as a privileged framework because of their wide distribution in various natural products and synthetic molecules and promising bioactivities. This review focuses on the recent advances in the synthesis of spiroheterocycles by using the strategy of N-heterocyclic carbene (NHC) organocatalysis, and is organized based on the stereoselectivity and the reactive interme...
متن کاملβ-Carbon activation of saturated carboxylic esters through N-heterocyclic carbene organocatalysis.
The activation of the α-carbons of carboxylic esters and related carbonyl compounds to generate enolate equivalents as nucleophiles is one of the most powerful strategies in organic synthesis. We reasoned that the horizons of chemical synthesis could be greatly expanded if the typically inert β-carbons of saturated esters could be used as nucleophiles. However, despite the rather significant fu...
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ژورنال
عنوان ژورنال: ChemSusChem
سال: 2019
ISSN: 1864-5631,1864-564X
DOI: 10.1002/cssc.201902346